Resistant to corrosion and heat in aggressive chemistry applications, custom-made Perfluoroalkoxy manifolds are constructed of translucent material that combines properties of PTFE and FEP and permits viewing of fluidic channel. Multilayer design uses bonding process that allows internal fluid paths which minimize connections and solution volumes while eliminating leak points. Manifolds can include SMT valves, pumps, sensors, fittings, and other components.